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Anti-biofilm Fe3O4@C18-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings

by 1,*, 1, 1, 2, 3, 4,5 and 4,5,6,*
Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90–92 Panduri Str., 050663 Bucharest, Romania
Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1–7 Polizu Street, 011061 Bucharest, Romania
Stefan S Nicolau Institute of Virology, Romanian Academy, 285 Mihai Bravu Ave., 030304 Bucharest, Romania
Department of Microbiology, Faculty of Biology, University of Bucharest, 1–3 Aleea Portocalelor St., 60101 Bucharest, Romania
Environment and Earth Sciences Department, Research Institute of the University of Bucharest—ICUB, Splaiul Independenţei 91–95, 050095 Bucharest, Romania
Academy of Romanian Scientists, 010071 Bucharest, Romania
Authors to whom correspondence should be addressed.
Materials 2020, 13(20), 4640;
Received: 7 September 2020 / Revised: 7 October 2020 / Accepted: 13 October 2020 / Published: 17 October 2020
The derivatives 5,7-dimethyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (1) and 7-methyl-5-phenyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (2) were fully characterized by single-crystal X-ray diffraction. Their supramolecular structure is built through both π–π stacking and C=S–π interactions for both compounds. The embedment of the tested compounds into Fe3O4@C18 core-shell nanocoatings increased the protection degree against Candida albicans biofilms on the catheter surface, suggesting that these bioactive nanocoatings could be further developed as non-cytotoxic strategies for fighting biofilm-associated fungal infections. View Full-Text
Keywords: [1,3,4]thiadiazolo[3,2-a]pyrimidine; molecular structure; coated catheter; Fe3O4@C18; biofilm; cytotoxicity [1,3,4]thiadiazolo[3,2-a]pyrimidine; molecular structure; coated catheter; Fe3O4@C18; biofilm; cytotoxicity
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Olar, R.; Badea, M.; Maxim, C.; Grumezescu, A.M.; Bleotu, C.; Măruţescu, L.; Chifiriuc, M.C. Anti-biofilm Fe3O4@C18-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings. Materials 2020, 13, 4640.

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