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Open AccessArticle

Anti-biofilm Fe3O4@C18-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings

by 1,*, 1, 1, 2, 3, 4,5 and 4,5,6,*
1
Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90–92 Panduri Str., 050663 Bucharest, Romania
2
Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1–7 Polizu Street, 011061 Bucharest, Romania
3
Stefan S Nicolau Institute of Virology, Romanian Academy, 285 Mihai Bravu Ave., 030304 Bucharest, Romania
4
Department of Microbiology, Faculty of Biology, University of Bucharest, 1–3 Aleea Portocalelor St., 60101 Bucharest, Romania
5
Environment and Earth Sciences Department, Research Institute of the University of Bucharest—ICUB, Splaiul Independenţei 91–95, 050095 Bucharest, Romania
6
Academy of Romanian Scientists, 010071 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Materials 2020, 13(20), 4640;
Received: 7 September 2020 / Revised: 7 October 2020 / Accepted: 13 October 2020 / Published: 17 October 2020
The derivatives 5,7-dimethyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (1) and 7-methyl-5-phenyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (2) were fully characterized by single-crystal X-ray diffraction. Their supramolecular structure is built through both π–π stacking and C=S–π interactions for both compounds. The embedment of the tested compounds into Fe3O4@C18 core-shell nanocoatings increased the protection degree against Candida albicans biofilms on the catheter surface, suggesting that these bioactive nanocoatings could be further developed as non-cytotoxic strategies for fighting biofilm-associated fungal infections. View Full-Text
Keywords: [1,3,4]thiadiazolo[3,2-a]pyrimidine; molecular structure; coated catheter; Fe3O4@C18; biofilm; cytotoxicity [1,3,4]thiadiazolo[3,2-a]pyrimidine; molecular structure; coated catheter; Fe3O4@C18; biofilm; cytotoxicity
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MDPI and ACS Style

Olar, R.; Badea, M.; Maxim, C.; Grumezescu, A.M.; Bleotu, C.; Măruţescu, L.; Chifiriuc, M.C. Anti-biofilm Fe3O4@C18-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings. Materials 2020, 13, 4640.

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