Search for Articles:
Title / Keyword
Author / Affiliation
Article Type
Special Issue
Logical OperatorOperator
Search Text
Search Type

Special Issue "Pathogenesis of Emerging Zoonotic Viral Infections"

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editors

Dr. Toshana Foster

Guest Editor
School of Veterinary Medicine and Science, University of Nottingham
Interests: host innate immune evasion by emerging pathogens; particularly arenaviruses, host-virus interactions, restriction factors, antivirals, structure-function relationships of viral proteins
Dr. Svetlana Khaiboullina

Guest Editor
Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
Interests: cytotoxic T lymphocytes (CTL); Multiple Sclerosis; central nervous system (CNS); Epstein Barr Virus (EBV); HERV
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The increasing emergence of zoonoses has devastating impacts on global public health and socio-economic development. Approximately 60% of all human infectious diseases are caused by zoonotic transmission from domestic animals, birds and wildlife; and an alarming 75% of recently emerged human infectious diseases are zoonotic in origin.Viral pathogens are a major threat worldwide; being responsible for significant disease emergence including highly pathogenetic avian influenza, Zika virus disease and viral haemorrhagic fevers caused by arenaviruses and Ebola viruses. The spread of these viral outbreaks can vary from confined clusters of cases to millions of cases globally, with hundreds of thousands or more, of associated deaths. Indeed, the current COVID-19 disease pandemic caused by a novel severe acute respiratory syndrome coronavirus, SARS-CoV-2, of animal origin, has led to significant morbidity and mortality rates, with substantial impact on public health resources and disruptions to global economic activity. The SARS-CoV-2 pandemic has highlighted the global challenges surrounding the detection and control strategies against zoonotic pathogens. Understanding the nature of viral zoonotic disease pathogenesis and unravelling the complex mechanisms involved in establishing infection and disease is crucial for identifying risk factors that influence transmission from reservoir hosts, and in providing key information that can improve diagnosis, treatment strategies and prevention. Further, studying the genetic diversity of emerging viruses and the molecular details of key differences in host innate and adaptive immune responses to infection, can expand our understanding of the host-virus co-evolution of hosts and impact on the development of antiviral vaccine and novel therapies. This Special Issue invites original research papers, reviews, and short communications about the pathogenesis of emerging and re-emerging zoonoses. Potential scope includes, but is not limited to: · Emerging and re-emerging virus infections· Genetic diversity and zoonotic potential· Virus-host interactions· Pathogenesis- entry, replication, spread· Molecular aspects of host immune responses· Diagnosis and disease management, i.e. prevention and control· SARS and SARS-CoV-2· Vaccines and therapeutics.

Dr. Toshana Foster
Dr. Svetlana Khaiboullina
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, . Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • zoonoses
  • emerging viruses
  • pandemic
  • outbreaks
  • coronaviruses
  • SARS-CoV-2
  • arenaviruses
  • hantaviruses
  • influenza
  • flaviviruses
  • filoviruses
  • bunyaviruses
  • henipaviruses
  • genetic diversity
  • host immunity
  • host restriction factors
  • diagnostics
  • therapeutic strategies
  • antivirals

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


Open AccessReview
Immunological Perspective for Ebola Virus Infection and Various Treatment Measures Taken to Fight the Disease
by , and
Pathogens 2020, 9(10), 850; - 17 Oct 2020
Ebolaviruses, discovered in 1976, belongs to the Filoviridae family, which also includes Marburg and Lloviu viruses. They are negative-stranded RNA viruses with six known species identified to date. Ebola virus (EBOV) is a member of Zaire ebolavirus species and can cause the Ebola [...] Read more.
Ebolaviruses, discovered in 1976, belongs to the Filoviridae family, which also includes Marburg and Lloviu viruses. They are negative-stranded RNA viruses with six known species identified to date. Ebola virus (EBOV) is a member of Zaire ebolavirus species and can cause the Ebola virus disease (EVD), an emerging zoonotic disease that results in homeostatic imbalance and multi-organ failure. There are three EBOV outbreaks documented in the last six years resulting in significant morbidity (> 32,000 cases) and mortality (> 13,500 deaths). The potential factors contributing to the high infectivity of this virus include multiple entry mechanisms, susceptibility of the host cells, employment of multiple immune evasion mechanisms and rapid person-to-person transmission. EBOV infection leads to cytokine storm, disseminated intravascular coagulation, host T cell apoptosis as well as cell mediated and humoral immune response. In this review, a concise recap of cell types targeted by EBOV and EVD symptoms followed by detailed run-through of host innate and adaptive immune responses, virus-driven regulation and their combined effects contributing to the disease pathogenesis has been presented. At last, the vaccine and drug development initiatives as well as challenges related to the management of infection have been discussed. Full article
(This article belongs to the Special Issue Pathogenesis of Emerging Zoonotic Viral Infections)
Back to TopTop