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Special Issue "Micro and Nanosensors for Biomedical"

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Physical Sensors".

Deadline for manuscript submissions: 28 February 2021.

Special Issue Editor

Dr. Daniel Ramos

Guest Editor
Instituto de Micro y Nanotecnologia (IMN-CSIC). 8, Isaac Newton (PTM), 28760 Tres Cantos, Madrid, Spain
Interests: physical sensors; optomechanics; nanophotonics; nanomechanics; nanofabrication; theoretical modelling; coupled systems; electromagnetic forces
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The development of biosensors with high sensitivity and high selectivity remains of paramount importance in diverse fields such as molecular biology, healthcare and food technology. Multidisciplinary research on nanotechnology has provided ultrasensitive nanobiosensors with a higher degree of miniaturization. In this sense, self-assembled monolayers (SAMs) are relevant biorecognition layers for molecular identification. However, it has been necessary to wait for the advent of nanotechnology tools, which have allowed the exploration of in-situ biologically relevant systems for shedding light on the nature of intermolecular interactions.

This Special Issue aims to gather the community and highlight the relevance of micro and nanodevices in the sensing field. We invite manuscripts for this forthcoming Special Issue on all aspects pertinent to nanosensors for biomedical applications, such as development, testing, and modeling of any kind of micro and nanosensors, advances in fabrication, etc.

We look forward to and welcome your participation in this Special Issue. Both experimental and theoretical contributions are welcome. Topics include, but are not limited to, the following research areas:

  • Biosensing and environmental analysis;
  • Molecular force sensing;
  • Nanomechanical sensing;
  • Optomechanical sensing;
  • Surface plasmon resonance sensors;
  • Fabrication of novel nanosensors platforms;
  • New micro and nanosensing schemes.

Dr. Daniel Ramos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, . Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Open AccessLetter
Microfluidic Production of Autofluorescent BSA Hydrogel Microspheres and Their Sequential Trapping for Fluorescence-Based On-Chip Permanganate Sensing
by , , , and
Sensors 2020, 20(20), 5886; - 17 Oct 2020
Microfabrication technologies have extensively advanced over the past decades, realizing a variety of well-designed compact devices for material synthesis, separation, analysis, monitoring, sensing, and so on. The performance of such devices has been undoubtedly improved, while it is still challenging to build up [...] Read more.
Microfabrication technologies have extensively advanced over the past decades, realizing a variety of well-designed compact devices for material synthesis, separation, analysis, monitoring, sensing, and so on. The performance of such devices has been undoubtedly improved, while it is still challenging to build up a platform by rationally combining multiple processes toward practical demands which become more diverse and complicated. Here, we present a simple and effective microfluidic system to produce and immobilize a well-defined functional material for on-chip permanganate (MnO4) sensing. A droplet-based microfluidic approach that can continuously produce monodispersed droplets in a water-in-oil system is employed to prepare highly uniform microspheres (average size: 102 μm, coefficient of variation: 3.7%) composed of bovine serum albumin (BSA) hydrogel with autofluorescence properties in the presence of glutaraldehyde (GA). Each BSA hydrogel microsphere is subsequently immobilized in a microchannel with a hydrodynamic trapping structure to serve as an independent fluorescence unit. Various anions such as Cl, NO3, PO43−, Br, BrO3, ClO4, SCN, HCO3, and MnO4 are individually flowed into the microchannel, resulting in significant fluorescence quenching only in the case of MnO4. Linear correlation is confirmed at an MnO4 concentration from 20 to 80 μM, and a limit of detection is estimated to be 1.7 μM. Furthermore, we demonstrate the simultaneous immobilization of two kinds of different microspheres in parallel microchannels, pure BSA hydrogel microspheres and BSA hydrogel microspheres containing rhodamine B molecules, making it possible to acquire two fluorescence signals (green and yellow). The present microfluidics-based combined approach will be useful to record a fingerprint of complicated samples for sensing/identification purposes by flexibly designing the size and composition of the BSA hydrogel microspheres, immobilizing them in a desired manner and obtaining a specific pattern. Full article
(This article belongs to the Special Issue Micro and Nanosensors for Biomedical)
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